Publications

Selected Publications

  • Cai, Y., Zheng, Z., Xu, H., Zhu, Y., Zepeda, J. C., Grueter, B. A., Wang, X., Ku, T., Duan, Y., Tsang, H. W. S., Fu, W. Y., Fu, A. K. Y., Mellios, N., Wong, H. H., Lai, K. O., & Ip, J. P. K. (2026). Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs. Science advances, 12(7), eads7509. Click here
  • Jenks, K. R., Cai, Y., Nayan, M. E., Tsimring, K., Li, K., Zepeda, J. C., Heller, G. R., Delepine, C., Shih, J., Yuan, S., Zhu, Y., Wang, Y., Duan, Y., Fu, A. K. Y., Ku, T., Yun, D. H., Chung, K., Mellios, N., Sur, M., & Ip, J. P. K. (2025). The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in the mouse visual cortex. iScience, 28(9), 113421. Click here
  • Tsimring, K., Jenks, K. R., Cusseddu, C., Heller, G. R., Ip, J. P. K., Gjorgjieva, J., & Sur, M. (2025). Large-scale synaptic dynamics drive the reconstruction of binocular circuits in mouse visual cortex. Nature communications, 16(1), 5810. Click here
  • So, T. W., Choi, H. Y., Xu, H., Zhu, J., Shi, L., & Ip, J. P. K. (2025). Hippocampal dorsal CA1: Functional connectivity and role in HCN channelopathies in affective diseases and epilepsy. IBRO neuroscience reports, 18, 644–656. Click here
  • Chen, W., Wu, J., Yang, C., Li, S., Liu, Z., An, Y., Wang, X., Cao, J., Xu, J., Duan, Y., Yuan, X., Zhang, X., Zhou, Y., Ip, J. P. K., Fu, A. K. Y., Ip, N. Y., Yao, Z., & Liu, K. (2024). Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America, 121(39), e2404395121. Click here
  • Yi, R., Chen, S., Guan, M., Liao, C., Zhu, Y., Ip, J. P. K., Ye, T., & Chen, Y. (2024). A single-cell transcriptomic dataset of pluripotent stem cell-derived astrocytes via NFIB/SOX9 overexpression. Scientific data, 11(1), 987. Click here
  • Jin, L., Sullivan, H. A., Zhu, M., Lavin, T. K., Matsuyama, M., Fu, X., Lea, N. E., Xu, R., Hou, Y., Rutigliani, L., Pruner, M., Babcock, K. R., Ip, J. P. K., Hu, M., Daigle, T. L., Zeng, H., Sur, M., Feng, G., & Wickersham, I. R. (2024). Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses. Nature Neuroscience, 27(2), 373–383. Click here
  • Chai, Y., Lee, S. S. Y., Shillington, A., Du, X., Fok, C. K. M., Yeung, K. C., Siu, G. K. Y., Yuan, S., Zheng, Z., Tsang, H. W. S., Gu, S., Chen, Y., Ye, T., & Ip, J. P. K. (2023). Non-canonical C-terminal variant of MeCP2 R344W exhibits enhanced degradation rate. IBRO Neuroscience Reports, 15, 218–224. Click here
  • Zhou, Z., Yip, H. M., Tsimring, K., Sur, M., Ip, J. P. K.#, & Tin, C#. (2023). Effective and efficient neural networks for spike inference from in vivo calcium imaging. Cell Reports Methods. Click here
    • #Co-correspondence
  • Guan, M., Chai, Y., Yi, R., Chen, Y., Ip, J. P. K., Ye, T., & Chen, Y. (2023). Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system. Stem Cell Research, 66, 103000–. Click here
  • Li, X., Chen, S.-C., & Ip, J. P. K. (2022). Diverse and Composite Roles of miRNA in Non-Neuronal Cells and Neuronal Synapses in Alzheimer’s Disease. Biomolecules (Basel, Switzerland), 12(10), 1505–. Click here
  • Yildirim, M., Delepine, C., Feldman, D., Pham, V. A., Chou, S., Ip, J., Nott, A., Tsai, L.-H., Ming, G.-L., So, P. T., & Sur, M. (2022). Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome. eLife, 11. Click here
  • Chow, C. F. W., Guo, X., Asthana, P., Zhang, S., Wong, S. K. K., Fallah, S., Che, S., Gurung, S., Wang, Z., Lee, K. B., Ge, X., Yuan, S., Xu, H., Ip, J. P. K., Jiang, Z., Zhai, L., Wu, J., Zhang, Y., Mahato, A. K., … Wong, H. L. X. (2022). Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nature Metabolism, 4(2), 203–212. Click here
  • Jenks, K. R., Tsimring, K., Ip, J. P. K., Zepeda, J. C., & Sur, M. (2021). Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits. Frontiers in Neural Circuits, 15, 803401–803401. Click here

Before 2020

  • Su, Y.T., Lau, S.F., Ip, J.P., Cheung, K., Cheung, T.H.T., Fu, A.K.Y., Ip, N.Y. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Proc. Natl. Acad. Sci., 2019, Jul 2; 116(27):13651-13660 Click here
  • El-Boustani, S.*, Ip, J.P.*, Breton-Provencher, V., Knott, G., Okuno, H., Bito, H., Sur, M. “Locally coordinated synaptic plasticity shapes cell-wide plasticity of visual cortex neurons in vivo” Science, 2018, Vol. 360, Issue 6395, pp. 1349-1354. Click here
  • Ip, J.P.*, Nagakura, I.*, Petravicz, J., Li,K., Wiemer, E.A.C., Sur, M. “Major vault protein, a candidate gene in 16p11.2 microdeletion syndrome, is required for the homeostatic regulation of visual cortical plasticity” Journal of Neuroscience, 2018, Apr 18;38(16):3890-3900. Click here
  • Ip, J.P., Mellios, N., Sur, M “Rett Syndrome: genetic, molecular and functional insights into multi-stage dysfunction” Nature Review Neuroscience, 2018, Jun; 19(6): 368-382. Review. Click here
  • Mellios, N.*, Feldman, D.*, Sheridan, S.D.*, Ip, J.P.*, Kwok, S., Amoah, S.K., Rosen, B., Rodriguez, B.A., Crawford, B., Swaminathan, R., Chou, S., Li, L., Ziats, M., Ernst, C., Jaenisch, R., Haggarty, S., Sur, M. “MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling” Molecular Psychiatry, 2018, Apr;23(4):1051-1065. Click here
    • *Equal contribution
    • Featured image: Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors. Molecular Psychiatry. 2018 Apr; 23(4):791. Click here
  • Ye, T., Ip, J.P., Fu, A.K., Ip, N.Y. “Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex” Nature Communications, 2014,5; 5: 4826 Click here
  • Tang, J., Ip, J.P., Ye, T., Ng, Y.P., Yung, W.H., Wu, Z., Fang, W., Fu, A.K., Ip, N.Y. “Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition” Journal of Neuroscience, 2014, 28; 34(22): 7425-36 Click here
  • Ip, J.P., Fu, A. K., Ip, N. Y. “CRMP2: Functional Roles in Neural Development and Therapeutic Potential in Neurological Diseases” The Neuroscientist, 2014, 20(6): 589-98. Review. Click here
  • Noçon, A.L., Ip, J.P., Terry, R., Lim, S.L., Getts, D.R., Müller, M., Hofer, M.J., King, N.J., Campbell, I.L. “The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis” Journal of Virology, 2013, 88(1): 679-89 Click here
  • Chen, Y., Fu, W.Y., Ip, J.P., Ye, T., Fu, A.K., Chao, M.V., Ip, N.Y. “Ankyrin Repeat-Rich Membrane Spanning Protein (Kidins220) Is Required for Neurotrophin and Ephrin Receptor-Dependent Dendrite Development” Journal of Neuroscience, 2012, 32(24): 8263-8269 Click here
  • Ip, J.P.*, Shi, L.*, Chen, Y., Itoh, Y., Fu, A. W., Betz, A., Yung, W. H., Gotoh, Y., Fu, A. K., Ip, N. Y. “α2-chimaerin controls neuronal migration and functioning of cerebral cortex through CRMP-2” Nature Neuroscience, 2012, (15) 39–47  (F1000 3 stars)Click here
  • Ip, J. P.*, Nocon, A. L.*, Hofer, M. J., Lim, S. L., Muller, M., Campbell, I. L. “Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration” J Neuroinflammation, 2011,8 (1) 124. Click here
    • *Equal contribution
  • Fang, W. Q., Ip, J. P., Li, R., Ng, Y. P., Lin, S. C., Chen, Y., Fu, A. K., Ip, N. Y. “Cdk5-mediated phosphorylation of axin directs axon formation during cerebral cortex development” Journal of Neuroscience, 2011, 31 (38) 13613-24 Click here
  • Farghaian, H., Chen, Y., Fu, A. W., Fu, A. K., Ip, J. P., Ip, N. Y., Turnley, A. M., Cole, A. R. “Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm” J Biol Chem, 2011, 286 (22) 19724-34 Click here